CHARACTERIZATION OF A FUNCTIONAL THROMBIN RECEPTOR - ISSUES AND OPPORTUNITIES
In this Perspectives, we review the recent cloning and characterization of a platelet thrombin receptor in our laboratory. Identification of the thrombin receptor did reveal a unique proteolytic mechanism of receptor activation, and led to the development of a novel agonist peptide which activates t...
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| Veröffentlicht in: | The Journal of clinical investigation 1992-02, Vol.89 (2), p.351-355 |
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| container_end_page | 355 |
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| container_issue | 2 |
| container_start_page | 351 |
| container_title | The Journal of clinical investigation |
| container_volume | 89 |
| creator | COUGHLIN VU, TKH HUNG, DT WHEATON |
| description | In this Perspectives, we review the recent cloning and characterization of a platelet thrombin receptor in our laboratory. Identification of the thrombin receptor did reveal a unique proteolytic mechanism of receptor activation, and led to the development of a novel agonist peptide which activates the thrombin receptor independent of thrombin and thrombin's protease activity. |
| doi_str_mv | 10.1172/JCI115592 |
| format | Article |
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| ispartof | The Journal of clinical investigation, 1992-02, Vol.89 (2), p.351-355 |
| issn | 0021-9738 1558-8238 |
| language | eng |
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| source | Web of Science - Science Citation Index Expanded - 1992<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Animals Biological and medical sciences Blood coagulation. Blood cells Fundamental and applied biological sciences. Psychology Humans Life Sciences & Biomedicine Medicine, Research & Experimental Molecular and cellular biology Molecular Sequence Data Platelet Platelet Membrane Glycoproteins - physiology Receptors, Cell Surface - analysis Receptors, Cell Surface - physiology Receptors, Thrombin Research & Experimental Medicine reviews Science & Technology thrombin Thrombin - physiology |
| title | CHARACTERIZATION OF A FUNCTIONAL THROMBIN RECEPTOR - ISSUES AND OPPORTUNITIES |
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