CHARACTERIZATION OF A FUNCTIONAL THROMBIN RECEPTOR - ISSUES AND OPPORTUNITIES

In this Perspectives, we review the recent cloning and characterization of a platelet thrombin receptor in our laboratory. Identification of the thrombin receptor did reveal a unique proteolytic mechanism of receptor activation, and led to the development of a novel agonist peptide which activates t...

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Veröffentlicht in:	The Journal of clinical investigation 1992-02, Vol.89 (2), p.351-355
Hauptverfasser:	COUGHLIN, VU, TKH, HUNG, DT, WHEATON
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biological and medical sciences Blood coagulation. Blood cells Fundamental and applied biological sciences. Psychology Humans Life Sciences & Biomedicine Medicine, Research & Experimental Molecular and cellular biology Molecular Sequence Data Platelet Platelet Membrane Glycoproteins - physiology Receptors, Cell Surface - analysis Receptors, Cell Surface - physiology Receptors, Thrombin Research & Experimental Medicine reviews Science & Technology thrombin Thrombin - physiology
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Beschreibung
Zusammenfassung:	In this Perspectives, we review the recent cloning and characterization of a platelet thrombin receptor in our laboratory. Identification of the thrombin receptor did reveal a unique proteolytic mechanism of receptor activation, and led to the development of a novel agonist peptide which activates the thrombin receptor independent of thrombin and thrombin's protease activity.
ISSN:	0021-9738 1558-8238
DOI:	10.1172/JCI115592