Retinoic acid and hydroquinone induce inverse expression patterns on cornified envelope-associated proteins: Implication in skin irritation

Highlights • DEGs on 1q21 locus showed an opposite expression pattern in response to RA and HQ. • RA-induced irritation reduced expression of cornified envelope-associated proteins. • HQ-induced irritation increased expression of cornified envelope-associated proteins. • The opposite expression in response to RA and HQ developed in vitro and in vivo. • The opposite expression developed in concentrations of varying irritation intensities.