Severe manifestations of extrapulmonary tuberculosis in HIV-infected children initiating antiretroviral therapy before 2 years of age

Background Early initiation of antiretroviral therapy (ART) in HIV-infected infants reduces mortality and opportunistic infections including tuberculosis (TB). However, young HIV-infected children remain at high risk of TB disease following mycobacterial infection. We document the spectrum of TB dis...

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Veröffentlicht in:	Archives of disease in childhood 2014-11, Vol.99 (11), p.998-1003
Hauptverfasser:	Walters, Elisabetta, Duvenhage, Joanie, Draper, Heather R, Hesseling, Anneke C, Van Wyk, Susan S, Cotton, Mark F, Rabie, Helena
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Antiretroviral agents Antiretroviral drugs Antiretroviral Therapy, Highly Active - methods Bacterial diseases Biological and medical sciences Care and treatment Children & youth Clinics Cohort Studies Communicable Diseases Complications and side effects Drug therapy Female Follow-Up Studies General aspects Guidelines Highly active antiretroviral therapy HIV infection in children HIV Infections - drug therapy Human bacterial diseases Humans Incidence Infant Infectious diseases Laboratories Male Medical sciences Miscellaneous Mortality National Standards Pediatric HIV infections Prevention and actions Public health Public health. Hygiene Public health. Hygiene-occupational medicine Retrospective Studies Risk Factors Software South Africa - epidemiology Statistical Analysis Tuberculosis Tuberculosis - diagnosis Tuberculosis and atypical mycobacterial infections Young Children
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Zusammenfassung:	Background Early initiation of antiretroviral therapy (ART) in HIV-infected infants reduces mortality and opportunistic infections including tuberculosis (TB). However, young HIV-infected children remain at high risk of TB disease following mycobacterial infection. We document the spectrum of TB disease in HIV-infected children
ISSN:	0003-9888 1468-2044
DOI:	10.1136/archdischild-2013-305509