Sensitive and selective DNA probe based on “turn-on” photoluminescence of C-dots@RGO
In this study, highly hydrophilic and photoluminescent sheets of reduced graphene oxide decorated with carbon dots (C-dots@RGO), methylene blue (MB), and a probe DNA have been used for the detection of DNA. The photoluminescence of C-dots@RGO is quenched by MB, which is restored in the presence of a...
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| Veröffentlicht in: | Analytical and bioanalytical chemistry 2014-11, Vol.406 (27), p.6917-6923 |
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| creator | Wang, Chen-I Wu, Wei-Cheng Periasamy, Arun Prakash Chang, Huan-Tsung |
| description | In this study, highly hydrophilic and photoluminescent sheets of reduced graphene oxide decorated with carbon dots (C-dots@RGO), methylene blue (MB), and a probe DNA have been used for the detection of DNA. The photoluminescence of C-dots@RGO is quenched by MB, which is restored in the presence of a target DNA. The combination of the C-dots@RGO, MB, and a DNA probe is selective for perfectly matched DNA over mismatched DNA, mainly because relative to single-stranded DNA, double-stranded DNA intercalates more strongly with MB, but interacts more weakly with RGO. In the presence of a target DNA, MB intercalates with the as-formed double-stranded DNA and is released from the surface of C-dots@RGO, leading to “turn-on” photoluminescence. The practicality of this assay has been validated by the determination of tumor suppressor gene BRCA1, with linearity over the concentration range from 25 to 250 nM and a limit of detection (LOD, at a signal-to-noise ratio of 3) of 14.6 nM. The C-dots@RGO probe provides higher specificity towards target DNA than towards common salts, carbohydrates, amino acids, and proteins found in real samples. Having the advantages of simplicity, cost-effectiveness, selectivity, and sensitivity, the DNA-P/C-dots@RGO–MB probe on microwells has been successfully employed for the detection of DNA, suggesting its potential for multiple analyses of DNA targets when various DNA probes are employed. |
| doi_str_mv | 10.1007/s00216-014-7658-2 |
| format | Article |
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The photoluminescence of C-dots@RGO is quenched by MB, which is restored in the presence of a target DNA. The combination of the C-dots@RGO, MB, and a DNA probe is selective for perfectly matched DNA over mismatched DNA, mainly because relative to single-stranded DNA, double-stranded DNA intercalates more strongly with MB, but interacts more weakly with RGO. In the presence of a target DNA, MB intercalates with the as-formed double-stranded DNA and is released from the surface of C-dots@RGO, leading to “turn-on” photoluminescence. The practicality of this assay has been validated by the determination of tumor suppressor gene BRCA1, with linearity over the concentration range from 25 to 250 nM and a limit of detection (LOD, at a signal-to-noise ratio of 3) of 14.6 nM. The C-dots@RGO probe provides higher specificity towards target DNA than towards common salts, carbohydrates, amino acids, and proteins found in real samples. Having the advantages of simplicity, cost-effectiveness, selectivity, and sensitivity, the DNA-P/C-dots@RGO–MB probe on microwells has been successfully employed for the detection of DNA, suggesting its potential for multiple analyses of DNA targets when various DNA probes are employed.</description><identifier>ISSN: 1618-2642</identifier><identifier>EISSN: 1618-2650</identifier><identifier>DOI: 10.1007/s00216-014-7658-2</identifier><identifier>PMID: 24553661</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Amino acids ; Analysis ; Analytical Chemistry ; Base Sequence ; Biochemistry ; BRCA1 protein ; Carbohydrates ; Carbon dots ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Deoxyribonucleic acid ; DNA ; DNA Probes ; Food Science ; Graphene ; Graphene in Analytics ; Intercalating agents ; Laboratory Medicine ; Linearity ; Luminescence ; Methylene blue ; Microscopy, Electron, Scanning ; Microscopy, Electron, Transmission ; Molecular Sequence Data ; Monitoring/Environmental Analysis ; Photoluminescence ; Photons ; Research Paper ; Salts ; Selectivity ; Signal to noise ratio ; Single-stranded DNA ; Tumor suppressor genes</subject><ispartof>Analytical and bioanalytical chemistry, 2014-11, Vol.406 (27), p.6917-6923</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>COPYRIGHT 2014 Springer</rights><rights>Springer-Verlag Berlin Heidelberg 2014.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-113dce845833fab9b83fd2f402c99e6850c4d233fbe7dd30b000401afe1e4f013</citedby><cites>FETCH-LOGICAL-c518t-113dce845833fab9b83fd2f402c99e6850c4d233fbe7dd30b000401afe1e4f013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00216-014-7658-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00216-014-7658-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24553661$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Chen-I</creatorcontrib><creatorcontrib>Wu, Wei-Cheng</creatorcontrib><creatorcontrib>Periasamy, Arun Prakash</creatorcontrib><creatorcontrib>Chang, Huan-Tsung</creatorcontrib><title>Sensitive and selective DNA probe based on “turn-on” photoluminescence of C-dots@RGO</title><title>Analytical and bioanalytical chemistry</title><addtitle>Anal Bioanal Chem</addtitle><addtitle>Anal Bioanal Chem</addtitle><description>In this study, highly hydrophilic and photoluminescent sheets of reduced graphene oxide decorated with carbon dots (C-dots@RGO), methylene blue (MB), and a probe DNA have been used for the detection of DNA. The photoluminescence of C-dots@RGO is quenched by MB, which is restored in the presence of a target DNA. The combination of the C-dots@RGO, MB, and a DNA probe is selective for perfectly matched DNA over mismatched DNA, mainly because relative to single-stranded DNA, double-stranded DNA intercalates more strongly with MB, but interacts more weakly with RGO. In the presence of a target DNA, MB intercalates with the as-formed double-stranded DNA and is released from the surface of C-dots@RGO, leading to “turn-on” photoluminescence. The practicality of this assay has been validated by the determination of tumor suppressor gene BRCA1, with linearity over the concentration range from 25 to 250 nM and a limit of detection (LOD, at a signal-to-noise ratio of 3) of 14.6 nM. The C-dots@RGO probe provides higher specificity towards target DNA than towards common salts, carbohydrates, amino acids, and proteins found in real samples. Having the advantages of simplicity, cost-effectiveness, selectivity, and sensitivity, the DNA-P/C-dots@RGO–MB probe on microwells has been successfully employed for the detection of DNA, suggesting its potential for multiple analyses of DNA targets when various DNA probes are employed.</description><subject>Amino acids</subject><subject>Analysis</subject><subject>Analytical Chemistry</subject><subject>Base Sequence</subject><subject>Biochemistry</subject><subject>BRCA1 protein</subject><subject>Carbohydrates</subject><subject>Carbon dots</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA Probes</subject><subject>Food Science</subject><subject>Graphene</subject><subject>Graphene in Analytics</subject><subject>Intercalating agents</subject><subject>Laboratory 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Huan-Tsung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sensitive and selective DNA probe based on “turn-on” photoluminescence of C-dots@RGO</atitle><jtitle>Analytical and bioanalytical chemistry</jtitle><stitle>Anal Bioanal Chem</stitle><addtitle>Anal Bioanal Chem</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>406</volume><issue>27</issue><spage>6917</spage><epage>6923</epage><pages>6917-6923</pages><issn>1618-2642</issn><eissn>1618-2650</eissn><abstract>In this study, highly hydrophilic and photoluminescent sheets of reduced graphene oxide decorated with carbon dots (C-dots@RGO), methylene blue (MB), and a probe DNA have been used for the detection of DNA. The photoluminescence of C-dots@RGO is quenched by MB, which is restored in the presence of a target DNA. The combination of the C-dots@RGO, MB, and a DNA probe is selective for perfectly matched DNA over mismatched DNA, mainly because relative to single-stranded DNA, double-stranded DNA intercalates more strongly with MB, but interacts more weakly with RGO. In the presence of a target DNA, MB intercalates with the as-formed double-stranded DNA and is released from the surface of C-dots@RGO, leading to “turn-on” photoluminescence. The practicality of this assay has been validated by the determination of tumor suppressor gene BRCA1, with linearity over the concentration range from 25 to 250 nM and a limit of detection (LOD, at a signal-to-noise ratio of 3) of 14.6 nM. The C-dots@RGO probe provides higher specificity towards target DNA than towards common salts, carbohydrates, amino acids, and proteins found in real samples. Having the advantages of simplicity, cost-effectiveness, selectivity, and sensitivity, the DNA-P/C-dots@RGO–MB probe on microwells has been successfully employed for the detection of DNA, suggesting its potential for multiple analyses of DNA targets when various DNA probes are employed.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>24553661</pmid><doi>10.1007/s00216-014-7658-2</doi><tpages>7</tpages></addata></record> |
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| subjects | Amino acids Analysis Analytical Chemistry Base Sequence Biochemistry BRCA1 protein Carbohydrates Carbon dots Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Deoxyribonucleic acid DNA DNA Probes Food Science Graphene Graphene in Analytics Intercalating agents Laboratory Medicine Linearity Luminescence Methylene blue Microscopy, Electron, Scanning Microscopy, Electron, Transmission Molecular Sequence Data Monitoring/Environmental Analysis Photoluminescence Photons Research Paper Salts Selectivity Signal to noise ratio Single-stranded DNA Tumor suppressor genes |
| title | Sensitive and selective DNA probe based on “turn-on” photoluminescence of C-dots@RGO |
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