Mandibular reconstruction using a calcium phosphate/polyethylene glycol hydrogel carrier with BMP-2
Aim To test the hypothesis that a synthetic hydroxyapatite/β‐tricalcium phosphate (HA/TCP) construct combined with polyethylene glycol (PEG) hydrogel including recombinant human bone morphogenetic proteins‐2 (rhBMP‐2) enhances new bone formation compared with bone morphogenetic proteins‐2 (BMP‐2) de...
Gespeichert in:
Veröffentlicht in: | Journal of clinical periodontology 2014-08, Vol.41 (8), p.820-826 |
---|---|
Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Aim
To test the hypothesis that a synthetic hydroxyapatite/β‐tricalcium phosphate (HA/TCP) construct combined with polyethylene glycol (PEG) hydrogel including recombinant human bone morphogenetic proteins‐2 (rhBMP‐2) enhances new bone formation compared with bone morphogenetic proteins‐2 (BMP‐2) delivered using the HA/TCP construct alone.
Material and Methods
Bilateral mandibular partial thickness 20 × 8 × 8 mm (L × W × H) alveolar defects were surgically created in the edentulated posterior mandible in 18 female minipigs. Randomized into two groups of nine animals each, the alveolar defects either received HA/TCP or HA/TCP/PEG with or without BMP‐2 (105 μg/defect) in contra‐lateral sites using a split‐mouth design. Primary outcome, bone density (%) within four regions of interest, was evaluated following a 4‐week healing interval when the animals were killed for histometric analysis.
Results
Bone morphogenetic proteins‐2 loaded onto HA/TCP constructs significantly enhanced new bone formation compared with HA/TCP controls. Adding PEG apparently obstructed BMP‐2 induced bone formation.
Conclusion
Polyethylene glycol compromises the osteogenic effect of BMP‐2. |
---|---|
ISSN: | 0303-6979 1600-051X |
DOI: | 10.1111/jcpe.12264 |