Mitochondrial DNA damage and atherosclerosis

Highlights • Emerging evidence indicates that mtDNA damage can directly promote atherosclerosis. • mtDNA damage and dysfunction increase inflammation. • Mitochondrial dysfunction does not necessarily lead to increased oxidative stress. • Protective mitochondrial pathways are potential therapeutic ta...

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Veröffentlicht in:	Trends in endocrinology and metabolism 2014-09, Vol.25 (9), p.481-487
Hauptverfasser:	Yu, Emma P.K, Bennett, Martin R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis atherosclerosis Atherosclerosis - etiology Atherosclerosis - immunology Atherosclerosis - metabolism DNA Damage DNA, Mitochondrial - chemistry DNA, Mitochondrial - metabolism Endocrinology & Metabolism Humans inflammation mitochondria Mitochondrial Dynamics Models, Biological Oxidative Stress
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Beschreibung
Zusammenfassung:	Highlights • Emerging evidence indicates that mtDNA damage can directly promote atherosclerosis. • mtDNA damage and dysfunction increase inflammation. • Mitochondrial dysfunction does not necessarily lead to increased oxidative stress. • Protective mitochondrial pathways are potential therapeutic targets.
ISSN:	1043-2760 1879-3061
DOI:	10.1016/j.tem.2014.06.008