The influence of nerve conduits diameter in motor nerve recovery after segmental nerve repair

Many conduits have demonstrated potential to substitute nerve autografts; however, the influence of conduit inner diameter (ID) has never been studied as a separate parameter. This experimental study compared motor recovery after segmental nerve repair with two different ID collagen conduits: 1.5 an...

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Veröffentlicht in:	Microsurgery 2014-11, Vol.34 (8), p.646-652
Hauptverfasser:	Giusti, Guilherme, Shin, Richard H., Lee, Joo-Yup, Mattar, Tiago G., Bishop, Allen T., Shin, Alexander Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Animals Collagen Disease Models, Animal Guided Tissue Regeneration Hindlimb Male Motor Activity - physiology Muscle Strength Nerve Regeneration - physiology Rats Rats, Inbred Lew Recovery of Function - physiology Sciatic Nerve - injuries Sciatic Nerve - physiopathology Sciatic Nerve - surgery
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Zusammenfassung:	Many conduits have demonstrated potential to substitute nerve autografts; however, the influence of conduit inner diameter (ID) has never been studied as a separate parameter. This experimental study compared motor recovery after segmental nerve repair with two different ID collagen conduits: 1.5 and 2.0 mm. In addition, the conduits were analyzed in vitro to determine the variations of ID before and after hydration. Thirty rats were divided into three groups: 2.0 mm ID, 1.5 mm ID, and a control group autograft. After 12 weeks, the 1.5 mm ID group demonstrated significant increase in force (P
ISSN:	0738-1085 1098-2752
DOI:	10.1002/micr.22312