A staging system for renal outcome and early markers of renal response to chemotherapy in AL amyloidosis

A staging system for renal outcome and early markers of renal response to chemotherapy in AL amyloidosis

The kidney is involved in 70% of patients with immunoglobulin light-chain (AL) amyloidosis, but little is known on progression or reversibility of renal involvement, and criteria for renal response have never been validated. Newly diagnosed patients from the Pavia (n = 461, testing cohort) and Heide...

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Veröffentlicht in:Blood 2014-10, Vol.124 (15), p.2325-2332
Hauptverfasser: Palladini, Giovanni, Hegenbart, Ute, Milani, Paolo, Kimmich, Christoph, Foli, Andrea, Ho, Anthony D., Rosin, Marta Vidus, Albertini, Riccardo, Moratti, Remigio, Merlini, Giampaolo, Schönland, Stefan
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Amyloidosis - drug therapy
Amyloidosis - pathology
Biomarkers - metabolism
Cohort Studies
Dialysis
Disease Progression
Female
Humans
Immunoglobulin Light Chains - metabolism
Immunoglobulin Light-chain Amyloidosis
Kidney - pathology
Male
Middle Aged
Proportional Hazards Models
Reproducibility of Results
Risk Factors
Survival Analysis
Time Factors
Treatment Outcome
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Zusammenfassung:The kidney is involved in 70% of patients with immunoglobulin light-chain (AL) amyloidosis, but little is known on progression or reversibility of renal involvement, and criteria for renal response have never been validated. Newly diagnosed patients from the Pavia (n = 461, testing cohort) and Heidelberg (n = 271, validation cohort) centers were included. Proteinuria >5 g/24 h and estimated glomerular filtration rate (eGFR)
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2014-04-570010