Specificity and the reliability of quantitation in the analysis of neurotransmitters
The unique advantages of selected ion monitoring, when using gas chromatography-mass spectrometry (GC-MS) as an analytical method for neurotransmitters are presented, using two examples: (1) paired quantitations of GABA from 11 brain regions, using different ion ratios of native and deuterated GABA:...
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| Veröffentlicht in: | Neurochemistry international 1991, Vol.19 (4), p.445-451 |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | The unique advantages of selected ion monitoring, when using gas chromatography-mass spectrometry (GC-MS) as an analytical method for neurotransmitters are presented, using two examples: (1) paired quantitations of GABA from 11 brain regions, using different ion ratios of native and deuterated GABA: (a)
m/z 190/194 and (b)
m/z 204/210. Of 44 data pairs of GABA concentration calculated using these ratios, only 2 differed by > 10%, 23 differed by |
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| ISSN: | 0197-0186 1872-9754 |
| DOI: | 10.1016/0197-0186(91)90062-I |