Diagnosis and management of drug allergy in adults, children and young people: summary of NICE guidance

All drugs have the potential to cause side effects or "adverse drug reactions," but not all of these are allergic in nature. The diagnosis of drug allergy can be challenging, and there is considerable variation both in how drug allergy is managed and in geographical access to specialist drug allergy services. On the basis of a National Institute for Health and Care Excellence (NICE) analysis of hospital episode statistics, about half a million people admitted to NHS hospitals each year in England and Wales have a diagnostic label of "drug allergy," with the most common being penicillin allergy. Fewer than 10% of people who think they are allergic to penicillin are truly allergic. Inadequate clinical documentation of allergic drug reactions and a lack of patient information (provided to and by patients) may lead to an inappropriate label of allergy to penicillin or other drugs remaining on a medical record. This can prevent future prescription even when clinically indicated. Here, Dworzynski et al discuss the most recent recommendations from NICE on drug allergy.