The human MHC : evidence for multiple HLA-D-region genes

The human major histocompatibiliy complex regulates immune responsiveness through a complex series of HLA-D-region-controlled molecules. The use of monoclonal antibodies to dissect this expanding array of molecules has allowed the structural characterization of several of these molecular species. Here biochemical studies are discussed which, coupled with classic serological techniques, have been used to construct a model of the genetic organization of the human HLA-D region.