Radial glial cell: Critical functions and new perspective as a steroid synthetic cell

Radial glial cell: Critical functions and new perspective as a steroid synthetic cell

Highlights • Radial glial cells form structural scaffolds to guide neuronal migration. • They serve as neuronal progenitors in adult brain. • Teleost radial glial cells produce estrogens from androgens. • These cells express steroidogenic acute regulatory protein and 17alpha-hydroxylase. • Radial gl...

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Veröffentlicht in:General and comparative endocrinology 2014-07, Vol.203, p.181-185
Hauptverfasser: Xing, L, Goswami, M, Trudeau, V.L
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Aromatase
Aromatase - metabolism
Endocrinology & Metabolism
Ependymoglial Cells - enzymology
Fishes - metabolism
Neurogenesis
Neurogenesis - physiology
Neuronal migration
Neurons - cytology
Neurons - physiology
Neurosteroid synthesis
Radial glial cell
Steroidogenic enzyme
Steroids - biosynthesis
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Zusammenfassung:Highlights • Radial glial cells form structural scaffolds to guide neuronal migration. • They serve as neuronal progenitors in adult brain. • Teleost radial glial cells produce estrogens from androgens. • These cells express steroidogenic acute regulatory protein and 17alpha-hydroxylase. • Radial glial cells have the potential for de novo steroid synthesis from cholesterol.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2014.03.010