Synthesis of nonadeuterated 1α,25-dihydroxyvitamin D2

•We have synthetized a deuterated vitamin D analogue, the 1a,25-dihydroxyvitamin D2 d9.•We have successfully achieved isotopic labelling. An efficient convergent synthesis of nonadeuterated 1α,25-dihydroxyvitamin D2 (1) by Pd(0)-catalyzed coupling between the boronate ester (upper fragment) and the...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2014-10, Vol.144, p.204-206
Hauptverfasser:	Sigüeiro, R., Álvarez, A., Otero, R., López-Pérez, B., Carballa, D., Regueira, T., González-Berdullas, P., Seoane, S., Pérez-Fernández, R., Mouriño, A., Maestro, M.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	1α,25-Dihydroxyvitamin D2 d9 Calcitriol - analogs & derivatives Calcitriol - chemical synthesis Chemistry Techniques, Synthetic Deuterium - chemistry Isotopic labelling Molecular Structure Palladium - chemistry Vitamin D2 analogues synthesis
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Beschreibung
Zusammenfassung:	•We have synthetized a deuterated vitamin D analogue, the 1a,25-dihydroxyvitamin D2 d9.•We have successfully achieved isotopic labelling. An efficient convergent synthesis of nonadeuterated 1α,25-dihydroxyvitamin D2 (1) by Pd(0)-catalyzed coupling between the boronate ester (upper fragment) and the enol triflate (A-ring fragment) is described. This article is part of a Special Issue entitled ‘16th Vitamin D Workshop’.
ISSN:	0960-0760 1879-1220
DOI:	10.1016/j.jsbmb.2013.10.025