Aging: Altered responsiveness of gastric mucosa to epidermal growth factor
The present investigation examines the responsiveness of the gastric mucosa to the growth-promoting action of epidermal growth factor (EGF) during advancing age. We conclude that aging is associated with increased gastric mucosal proliferative activity and that exogenous EGF exerts an antiproliferat...
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| Veröffentlicht in: | American Journal of Physiology: Cell Physiology 1989-01, Vol.257 (4), p.G554-G560 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | The present investigation examines the responsiveness of the gastric mucosa to the growth-promoting action of epidermal growth factor (EGF) during advancing age. We conclude that aging is associated with increased gastric mucosal proliferative activity and that exogenous EGF exerts an antiproliferative effect on the gastric mucosa of aged rats. We also suggest that tyrosine kinases play a role in determining these events. (DBO) |
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| ISSN: | 0363-6143 |