Comparative mutagenic and genotoxic effects of three propionic acid derivatives ibuprofen, ketoprofen and naproxen

The mutagenicity of three propionic acid derivatives, namely ibuprofen, ketoprofen and naproxen, was tested in the Ames mutagenicity assay (in strains TA97a, TA100 and TA102) and in vivo genotoxicity was tested by sister chromatid exchange (SCE) in bone marrow cells of mice. These are the anti-infla...

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Veröffentlicht in:	Mutation research 1997-09, Vol.393 (1), p.123-131
Hauptverfasser:	Philipose, B, Singh, R, Khan, K.A, Giri, A.K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - toxicity Bone Marrow Cells - drug effects Genotoxicity Ibuprofen Ibuprofen - toxicity In Vitro Techniques Ketoprofen Ketoprofen - toxicity Male Mice Microsomes, Liver - metabolism Mouse Mutagenicicity Mutagenicity Tests Mutagens - toxicity Naproxen Naproxen - toxicity Rats Salmonella Salmonella typhimurium - drug effects Salmonella typhimurium - genetics Sister Chromatid Exchange - drug effects
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Zusammenfassung:	The mutagenicity of three propionic acid derivatives, namely ibuprofen, ketoprofen and naproxen, was tested in the Ames mutagenicity assay (in strains TA97a, TA100 and TA102) and in vivo genotoxicity was tested by sister chromatid exchange (SCE) in bone marrow cells of mice. These are the anti-inflammatory drugs frequently used in different parts of the world. Mutagenicity results showed no mutagenic effects in strains TA97a, TA100 and TA102 for all three drugs. Results of in vivo SCE assays indicate that these three drugs are weakly genoxic in bone marrow cells of mice. This is the first report of the Ames mutagenicity assay for ketoprofen and in vivo SCE assay for three drugs.
ISSN:	1383-5718 0027-5107 1879-3592
DOI:	10.1016/S1383-5718(97)00095-8