Quercetin-induced lipid peroxidation and DNa damage in isolated rat-liver nuclei

The extent of lipid peroxidation and DNA damage induced by quercetin were studied under aerobic conditions in isolated rat-liver nuclei. The effects of iron and copper ions on these two toxic oxidative processes were also investigated. Quercetin induced significant (P < 0.05) concentration-depend...

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Veröffentlicht in:	Cancer letters 1991-06, Vol.58 (1), p.75-79
Hauptverfasser:	Sahu, S.C., Washington, M.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carcinogens Cell Nucleus - drug effects Cell Nucleus - metabolism Copper - pharmacology Diet DNA Damage flavonoids Free Radicals Fundamental and applied biological sciences. Psychology Iron - pharmacology Lipid Peroxidation Liver - drug effects Liver - metabolism Male Molecular and cellular biology Oxidation-Reduction oxygen radical quercetin Quercetin - administration & dosage Quercetin - pharmacology Rats Rats, Inbred Strains
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Zusammenfassung:	The extent of lipid peroxidation and DNA damage induced by quercetin were studied under aerobic conditions in isolated rat-liver nuclei. The effects of iron and copper ions on these two toxic oxidative processes were also investigated. Quercetin induced significant (P < 0.05) concentration-dependent nuclear lipid peroxidation concurrent with DNA degradation; these effects were enhanced by iron and copper ions. The results suggest that the reactive oxygen species generated by quercetin autoxidation, catalyzed by iron and copper ions, are responsible for the concurrent lipid peroxidation and DNA damage in isolated rat-liver nuclei.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/0304-3835(91)90026-E