Combined toxicity of fluoride and benzene hexachloride to rats

Combined toxicity of fluoride and benzene hexachloride to rats

Sprague-Dawley rats were given various treatments of 10 ppm fluoride, 25 ppm fluoride, 25 ppm benzene hexachloride (BHC), 10 ppm fluoride + 25 ppm BHC, or 25 ppm fluoride + 25 ppm BHC for 16 weeks ad libitum. Rats showed a decrease in body weight gain, which could be attributable to BHC alone. A syn...

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Veröffentlicht in:Fluoride 1997-05, Vol.30 (2), p.105-109
Hauptverfasser: Ramesh, N, Mohan, E M, Priya, CAYB, Stanley, V A, Pillai, K S, Murthy, P B
Format: Artikel
Sprache:eng
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Zusammenfassung:Sprague-Dawley rats were given various treatments of 10 ppm fluoride, 25 ppm fluoride, 25 ppm benzene hexachloride (BHC), 10 ppm fluoride + 25 ppm BHC, or 25 ppm fluoride + 25 ppm BHC for 16 weeks ad libitum. Rats showed a decrease in body weight gain, which could be attributable to BHC alone. A synergistic effect of fluoride and BHC was seen only in females given 25 ppm fluoride + 25 ppm BHC: a decrease in red blood cells (RBC) and relative weight of the ovary. Females were more susceptible to the toxicity of fluoride and BHC than males.
ISSN:0015-4725