Reduced high density lipoprotein cholesterol in human cholesteryl ester transfer protein transgenic mice

Reduced high density lipoprotein cholesterol in human cholesteryl ester transfer protein transgenic mice

The human cholesteryl ester transfer protein (CETP) facilitates the exchange of neutral lipids among lipoproteins. In order to evaluate the effects of increased plasma CETP on lipoprotein levels, a human CETP minigene was placed under the control of the mouse metallothionein-I promoter and used to d...

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Veröffentlicht in:The Journal of biological chemistry 1991-01, Vol.226 (17), p.10796-10801
Hauptverfasser: Agellon, L B, Walsh, A, Hayek, T, Moulin, P, Jiang, Xian Cheng, Shelanski, SA, Breslow, J L, Tall, A R
Format: Artikel
Sprache:eng
Schlagworte:
cholesterol
genes
metallothionein-I
promoters
zinc
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Zusammenfassung:The human cholesteryl ester transfer protein (CETP) facilitates the exchange of neutral lipids among lipoproteins. In order to evaluate the effects of increased plasma CETP on lipoprotein levels, a human CETP minigene was placed under the control of the mouse metallothionein-I promoter and used to develop transgenic mice. The results suggest that high levels of plasma CETP activity may be a cause of reduced high density lipoproteins in humans.
ISSN:0021-9258