Effect of dibutyltin dilaurate on regional brain polyamines in rats

Administration of dibutyltin dilaurate (DBTL; 0, 20 or 40 mg/kg body wt.) by gavage to rats for 3 consecutive days produced a significant increase in polyamine levels in selected brain areas. At the higher dose of DBTL (40 mg/kg) Spermidine levels were raised in pons-medulla, hypothalamus and fronta...

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Veröffentlicht in:	Toxicology letters 1991-02, Vol.55 (2), p.179-183
Hauptverfasser:	Khaliq, M.A., Husain, R., Seth, P.K., Srivastava, S.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthelmintics - toxicity Biological and medical sciences body weight Body Weight - drug effects brain Brain - drug effects Brain - metabolism Brain regions Chemical and industrial products toxicology. Toxic occupational diseases Dibutyltin dilaurate Female Medical sciences Metals and various inorganic compounds Neurotoxicity neurotoxins Organotin Compounds - toxicity Rats Rats, Inbred Strains Spermidine Spermidine - metabolism Spermine Spermine - metabolism Toxicology
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Zusammenfassung:	Administration of dibutyltin dilaurate (DBTL; 0, 20 or 40 mg/kg body wt.) by gavage to rats for 3 consecutive days produced a significant increase in polyamine levels in selected brain areas. At the higher dose of DBTL (40 mg/kg) Spermidine levels were raised in pons-medulla, hypothalamus and frontal cortex while spermine levels increased in pons-medulla, hippocampus and frontal cortex regions. At the lower dose (20 mg/kg) only a slight increase in polyamine levels occurred. The observed induction in regional brain polyamines in DBTL-treated rats may lead to disturbances in synaptic function and further enhance its neurotoxic potential.
ISSN:	0378-4274 1879-3169
DOI:	10.1016/0378-4274(91)90132-P