Structure—activity relationships of synthetic diosgenyl monoglycosides

Hemolytic or antifungal activities of seven synthetic diosgenyl and three cholesteryl monoglycosides were compared with each other. The hemolytic activities of these glycosides were as weak as those of their aglycones, but the antifungal activities of diosgenyl glucoside and galactoside were much hi...

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Veröffentlicht in:	Phytochemistry (Oxford) 1991, Vol.30 (8), p.2557-2558
Hauptverfasser:	Takechi, Masayuki, Tanaka, Yasuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry antifungal activity antifungal properties Biological and medical sciences Carbohydrates chemical degradation chemical structure cholesterol cholesteryl esters diosgenin Fundamental and applied biological sciences. Psychology glycosides hemolysis Heterosides Other biological molecules plant extracts Structure-activity relationships synthetic monoglycosides
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Zusammenfassung:	Hemolytic or antifungal activities of seven synthetic diosgenyl and three cholesteryl monoglycosides were compared with each other. The hemolytic activities of these glycosides were as weak as those of their aglycones, but the antifungal activities of diosgenyl glucoside and galactoside were much higher than those of the other glycosides. The E and F rings of diosgenin are important for activity.
ISSN:	0031-9422 1873-3700
DOI:	10.1016/0031-9422(91)85099-L