Studies on two new lymph imaging agents and their clinical application

Liposome and PG kit were labeled with the 99mTcO 4 to form 99mTc-liposome and 99mTc-PG which are two non-invasive, safe diagnostic drugs. The labeling efficiency of the agents are more than 95%. The 99mTc imaging agents in the PLN as compared with the other different organs showed that the ratio value of PLN to other organ is more than 149 times after 30 min i.d. injection of 99mTc-liposome and the ratio value is more than 30.19 times after 2 h i.d. injection of 99mTc-PG. The studies of the pharmacokinetics and mechanism of imaging have been carried out. The 99mTc-liposome was administrated to more than 140 patients and 99mTc-PG was administrated to more than 5000 patients. The clinical tests were satisfactory and no side-effect was shown.