Transforming growth factor beta sub(1) inhibits epidermal growth factor receptor endocytosis and down-regulation in cultured fetal rat hepatocytes

Transforming growth factor beta sub(1) inhibits epidermal growth factor receptor endocytosis and down-regulation in cultured fetal rat hepatocytes

Incubation of fetal rat hepatocytes (FRH) with transforming growth factor beta sub(1) (TGF- beta sub(1)) resulted in growth arrest and a biphasic effect on epidermal growth factor (EGF) receptor. The observations provide direct evidence that TGF- beta sub(1) regulates growth of fetal cells. Further,...

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Veröffentlicht in:The Journal of biological chemistry 1991-01, Vol.266 (20), p.13238-13242
Hauptverfasser: Baskin, G, Schenker, S, Frosto, T, Henderson, G
Format: Artikel
Sprache:eng
Schlagworte:
epidermal growth factor
fetuses
hepatocytes
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Zusammenfassung:Incubation of fetal rat hepatocytes (FRH) with transforming growth factor beta sub(1) (TGF- beta sub(1)) resulted in growth arrest and a biphasic effect on epidermal growth factor (EGF) receptor. The observations provide direct evidence that TGF- beta sub(1) regulates growth of fetal cells. Further, they suggest that TGF- beta sub(1) regulates endocytosis of EGF and possibly of other ligands.
ISSN:0021-9258