Genetic difference in sensitivity to β-carboline: Evidence for the involvement of brain benzodiazepine receptors

The convulsive effects of methyl β-carboline-3-car☐ylate (β-CCM), a benzodiazepine receptor ligand, are different in two inbred strains of mice: BALB/cBy mice are more sensitive to β-CCM than C57BL/6J mice. In the present article, we report the effects of [3H]flunitrazepam binding in these two strai...

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Veröffentlicht in:	Brain research 1991-07, Vol.553 (2), p.342-346
Hauptverfasser:	Chapouthier, Georges, Bondoux, Dominique, Martin, Benoit, Desforges, Carole, Launay, Jean-Marie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BALB/cBy Benzodiazepine Benzodiazepine receptor Binding Biological and medical sciences Brain - metabolism C57BL/6J Carbolines - pharmacology Clonazepam - pharmacology Convulsants - pharmacology Flunitrazepam Flunitrazepam - metabolism Inbred mouse strain Kinetics Medical sciences Methyl β-carboline-3-car☐ylate Mice Mice, Inbred BALB C Mice, Inbred C57BL Nervous system involvement in other diseases. Miscellaneous Neurology Receptors, GABA-A - drug effects Receptors, GABA-A - metabolism Seizure Seizures - physiopathology Species Specificity Strychnine - toxicity β-Carboline
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Zusammenfassung:	The convulsive effects of methyl β-carboline-3-car☐ylate (β-CCM), a benzodiazepine receptor ligand, are different in two inbred strains of mice: BALB/cBy mice are more sensitive to β-CCM than C57BL/6J mice. In the present article, we report the effects of [3H]flunitrazepam binding in these two strains, which suggest a possible explanation of the differences in their sensitivity to β-CCM by the involvement of brain benzodiazepine receptors.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(91)90847-O