Murine hepatic p53, RB, and CDK inhibitory protein expression following acute 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure

This study examined the expression of murine hepatic tumor suppressor and cell cycle inhibitory proteins in response to acute 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) dosing in Balb/c mice. Elevations in expression of p53, retinoblastoma (Rb) protein, p16 Ink4 , p21 Wafl and p27 Kipl were observe...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemosphere (Oxford) 1997-03, Vol.34 (5), p.1557-1568
Hauptverfasser:	Rininger, Joseph A., Stoffregen, Dana A., Babish, John G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Carrier Proteins - biosynthesis Cell Cycle - drug effects Cell Division - drug effects Chemical agents Cyclin-Dependent Kinase Inhibitor p16 Cyclin-Dependent Kinases - antagonists & inhibitors Enzyme Inhibitors - metabolism Female Genes, p53 Genes, Tumor Suppressor Liver - drug effects Liver - metabolism Medical sciences Mice Mice, Inbred BALB C Polychlorinated Dibenzodioxins - toxicity Retinoblastoma Protein - biosynthesis Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	This study examined the expression of murine hepatic tumor suppressor and cell cycle inhibitory proteins in response to acute 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) dosing in Balb/c mice. Elevations in expression of p53, retinoblastoma (Rb) protein, p16 Ink4 , p21 Wafl and p27 Kipl were observed six days after a single dose of 0.25, 0.5, 1 or 2 μg TCDD/kg. These data suggest that the TCDD-induced inhibition of hepatocyte proliferation in vivo could be attributed to the expression of cell cycle inhibitory proteins.
ISSN:	0045-6535 1879-1298
DOI:	10.1016/S0045-6535(96)00451-1