The inhibition of ( super(125)I) omega -conotoxin GVIA binding to neuronal membranes by neomycin may be mediated by a GTP-binding protein

The inhibition of ( super(125)I) omega -conotoxin GVIA binding to neuronal membranes by neomycin may be mediated by a GTP-binding protein

omega -Conotoxin GVIA ( omega -CT) has been reported to block calcium currents at the L- and N-type calcium channels. In neuronal membranes omega -CT, and the aminoglycoside antibiotic neomycin, have been shown to inhibit ( super(125)I) omega -CT binding, presumably acting at the N-type calcium chan...

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Veröffentlicht in:European journal of pharmacology 1991-01, Vol.206 (2), p.155-158
Hauptverfasser: Stumpo, R J, Pullan, L M, Salama, AI
Format: Artikel
Sprache:eng
Schlagworte:
calcium
guanine nucleotide-binding proteins
omega -conotoxin GVIA
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Zusammenfassung:omega -Conotoxin GVIA ( omega -CT) has been reported to block calcium currents at the L- and N-type calcium channels. In neuronal membranes omega -CT, and the aminoglycoside antibiotic neomycin, have been shown to inhibit ( super(125)I) omega -CT binding, presumably acting at the N-type calcium channel. We demonstrate here that the concentration curve for neomycin sulfate inhibition of ( super(125)I) omega -CT binding is shifted to the right by GTP analogues or fluoride, increasing the IC sub(50) for neomycin.
ISSN:0014-2999