Ubiquinone concentration in control chorionic villi and fetal liver

Ubiquinone concentration in control chorionic villi and fetal liver

Ubiquinone (CoQ 10) plays an important role as an electron carrier between flavin-dependent dehydrogenases (complexes I and II) and complex III of the respiratory chain. A severe muscular CoQ 10 deficiency has recently been described in two female patients with hyperlactacidemia, encephalomyopathy,...

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Veröffentlicht in:Prenatal diagnosis 1991-03, Vol.11 (3), p.206-206
Hauptverfasser: Charpentier, Christiane, Chadefaux, Bernadette, Aupetit, Joelle, Harpey, Jean-Paul
Format: Artikel
Sprache:eng
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Zusammenfassung:Ubiquinone (CoQ 10) plays an important role as an electron carrier between flavin-dependent dehydrogenases (complexes I and II) and complex III of the respiratory chain. A severe muscular CoQ 10 deficiency has recently been described in two female patients with hyperlactacidemia, encephalomyopathy, and low activities of complexes I-II and II-III. Perhaps, prenatal evaluation of CoQ 10 in chorionic villi and possibly in fetal liver could provide indications for a treatment in utero.
ISSN:0197-3851
1097-0223
DOI:10.1002/pd.1970110312