Dolastatins. 26. Synthesis and stereochemistry of dolastatin 11

Dolastatins. 26. Synthesis and stereochemistry of dolastatin 11

The first synthesis of dolastatin 11, a potent antineoplastic agent from the sea hare Dolabella auricularia, confirmed the proposed structure and established the last configuration in this natural product and in dolastatin 12, majusculamide C, and 57-normajusculamide C.

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Veröffentlicht in:Journal of the American Chemical Society 1997-03, Vol.119 (9), p.2111-2113
Hauptverfasser: Bates, R B, Brusoe, K G, Burns, J J, Caldera, S, Cui, Wei, Gangwar, S, Gramme, M R, McClure, K J, Rouen, G P, Schadow, H, Stessman, C C, Taylor, SR, Vu, V H, Yarick, G V
Format: Artikel
Sprache:eng
Schlagworte:
Dolabella auricularia
Marine
Mollusca
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Zusammenfassung:The first synthesis of dolastatin 11, a potent antineoplastic agent from the sea hare Dolabella auricularia, confirmed the proposed structure and established the last configuration in this natural product and in dolastatin 12, majusculamide C, and 57-normajusculamide C.
ISSN:0002-7863
DOI:10.1021/ja963857y