A novel rapid throughput phototolerance screen in mice
A relatively simple, rapid throughput phototolerance screen in small animals would be very useful in early drug development. It could prioritize or select potential lead compounds from among a number of analogs with similar biological activities. This study describes an in vivo mouse phototolerance...
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| Veröffentlicht in: | Journal of pharmacological and toxicological methods 1996-12, Vol.36 (4), p.185-187 |
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| Sprache: | eng |
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| container_end_page | 187 |
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| container_issue | 4 |
| container_start_page | 185 |
| container_title | Journal of pharmacological and toxicological methods |
| container_volume | 36 |
| creator | Shapiro, Martin A. Sesnie, Josephine C. Joannides, E.Themis Malta, Thomas E. Dever, Julie A. Heifetz, Carl L. |
| description | A relatively simple, rapid throughput phototolerance screen in small animals would be very useful in early drug development. It could prioritize or select potential lead compounds from among a number of analogs with similar biological activities. This study describes an in vivo mouse phototolerance screen established for that purpose. It also reports phototolerance data with standard reference drugs obtained using this screen. |
| doi_str_mv | 10.1016/S1056-8719(96)00109-8 |
| format | Article |
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It also reports phototolerance data with standard reference drugs obtained using this screen.</description><subject>Animals</subject><subject>Dermatitis, Phototoxic - etiology</subject><subject>Drug Evaluation, Preclinical - methods</subject><subject>Female</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Mouse model</subject><subject>Phototolerance</subject><subject>Quinolones - toxicity</subject><subject>Rapid screening method</subject><subject>Skin Diseases - chemically induced</subject><subject>Skin Diseases - etiology</subject><subject>Toxicology - methods</subject><issn>1056-8719</issn><issn>1873-488X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMoq67-hIWeRA_VCWnT5CTL4hcseFDBW2iTiRvpl0m74L83-6FXmcMMzPvOyzyEzChcU6D85oVCzlNRUHkp-RUABZmKA3JCRcHSTIj3wzj_So7JaQifAMAkzSZkIiGLBnFC-DxpuzXWiS97Z5Jh5bvxY9WPQ9KvuiFWjb5sNSZBe8Q2cW3SOI1n5MiWdcDzfZ-St_u718Vjunx-eFrMl6lmTA4p0zoGYlEZIVleSAlVhYgmB4wCzRDBGJ5racrCgNTWZgCl1citsaJibEoudnd7332NGAbVuKCxrssWuzEomkueC0GjMN8Jte9C8GhV711T-m9FQW14qS0vtYGhJFdbXkpE32wfMFYNmj_XHlDc3-72GL9cO_QqaIcRiHEe9aBM5_5J-AFx1Xt8</recordid><startdate>19961201</startdate><enddate>19961201</enddate><creator>Shapiro, Martin A.</creator><creator>Sesnie, Josephine C.</creator><creator>Joannides, E.Themis</creator><creator>Malta, Thomas E.</creator><creator>Dever, Julie A.</creator><creator>Heifetz, Carl L.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19961201</creationdate><title>A novel rapid throughput phototolerance screen in mice</title><author>Shapiro, Martin A. ; Sesnie, Josephine C. ; Joannides, E.Themis ; Malta, Thomas E. ; Dever, Julie A. ; Heifetz, Carl L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-3cc391e7bd89357990bbeeed50ec33c3ee0dd65c9da7d09cff400afce6fdf8b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Dermatitis, Phototoxic - etiology</topic><topic>Drug Evaluation, Preclinical - methods</topic><topic>Female</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Mouse model</topic><topic>Phototolerance</topic><topic>Quinolones - toxicity</topic><topic>Rapid screening method</topic><topic>Skin Diseases - chemically induced</topic><topic>Skin Diseases - etiology</topic><topic>Toxicology - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shapiro, Martin A.</creatorcontrib><creatorcontrib>Sesnie, Josephine C.</creatorcontrib><creatorcontrib>Joannides, E.Themis</creatorcontrib><creatorcontrib>Malta, Thomas E.</creatorcontrib><creatorcontrib>Dever, Julie A.</creatorcontrib><creatorcontrib>Heifetz, Carl L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of pharmacological and toxicological methods</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shapiro, Martin A.</au><au>Sesnie, Josephine C.</au><au>Joannides, E.Themis</au><au>Malta, Thomas E.</au><au>Dever, Julie A.</au><au>Heifetz, Carl L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A novel rapid throughput phototolerance screen in mice</atitle><jtitle>Journal of pharmacological and toxicological methods</jtitle><addtitle>J Pharmacol Toxicol Methods</addtitle><date>1996-12-01</date><risdate>1996</risdate><volume>36</volume><issue>4</issue><spage>185</spage><epage>187</epage><pages>185-187</pages><issn>1056-8719</issn><eissn>1873-488X</eissn><abstract>A relatively simple, rapid throughput phototolerance screen in small animals would be very useful in early drug development. 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| fulltext | fulltext |
| identifier | ISSN: 1056-8719 |
| ispartof | Journal of pharmacological and toxicological methods, 1996-12, Vol.36 (4), p.185-187 |
| issn | 1056-8719 1873-488X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_15965881 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Animals Dermatitis, Phototoxic - etiology Drug Evaluation, Preclinical - methods Female Mice Mice, Inbred Strains Mouse model Phototolerance Quinolones - toxicity Rapid screening method Skin Diseases - chemically induced Skin Diseases - etiology Toxicology - methods |
| title | A novel rapid throughput phototolerance screen in mice |
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