A novel rapid throughput phototolerance screen in mice

A relatively simple, rapid throughput phototolerance screen in small animals would be very useful in early drug development. It could prioritize or select potential lead compounds from among a number of analogs with similar biological activities. This study describes an in vivo mouse phototolerance...

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Veröffentlicht in:	Journal of pharmacological and toxicological methods 1996-12, Vol.36 (4), p.185-187
Hauptverfasser:	Shapiro, Martin A., Sesnie, Josephine C., Joannides, E.Themis, Malta, Thomas E., Dever, Julie A., Heifetz, Carl L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dermatitis, Phototoxic - etiology Drug Evaluation, Preclinical - methods Female Mice Mice, Inbred Strains Mouse model Phototolerance Quinolones - toxicity Rapid screening method Skin Diseases - chemically induced Skin Diseases - etiology Toxicology - methods
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	A relatively simple, rapid throughput phototolerance screen in small animals would be very useful in early drug development. It could prioritize or select potential lead compounds from among a number of analogs with similar biological activities. This study describes an in vivo mouse phototolerance screen established for that purpose. It also reports phototolerance data with standard reference drugs obtained using this screen.
ISSN:	1056-8719 1873-488X
DOI:	10.1016/S1056-8719(96)00109-8