Tissue Injury and Repair as Parallel and Opposing Responses to CCl sub(4) Hepatotoxicity: A Novel Dose-Response

Male rats were given a wide range of ip doses of carbon tetrachloride, up to 4 ml/kg, and monitored for liver damage and repair. At doses up to 2 ml/kg, a dose dependent increase in cell division was noted, that indicated that tissue repair was ongoing. At higher doses, repair of tissue slowed and lessened. At the higher doses, tissue injury was more rapid. The highest dose was lethal to 80% of the rats, but in the survivors, tissue repair increased five times. The amount of injury affects the repair response, and the time that initiation of repair occurs is also important to the final outcome.