Diverse molecular provocation of programmed cell death

The experimental study and manipulation of programmed cell death has been greatly assisted by the identification of genetic and pharmacological tools that can either induce or block cell lethality. This review discusses new insights into the molecular sensing of perturbations induced by such tools,...

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Veröffentlicht in:	Trends in biochemical sciences (Amsterdam. Regular ed.) 1996-10, Vol.21 (10), p.359-364
Hauptverfasser:	Wertz, I E, Hanley, M R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid - pharmacology Apoptosis - drug effects Apoptosis - genetics Apoptosis - physiology Chelating Agents - pharmacology Cytoskeleton - chemistry DNA Damage - genetics Ion Channels - metabolism Oxidants - pharmacology Receptors, Cell Surface - metabolism Signal Transduction - genetics Tumor Necrosis Factor-alpha - pharmacology
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Beschreibung
Zusammenfassung:	The experimental study and manipulation of programmed cell death has been greatly assisted by the identification of genetic and pharmacological tools that can either induce or block cell lethality. This review discusses new insights into the molecular sensing of perturbations induced by such tools, as well as the possible consequences of this detection in determining cell survival.
ISSN:	0968-0004
DOI:	10.1016/0968-0004(96)40002-0