Critical care for clonidine poisoning in toddlers
Clonidine may be a source of serious toxicity when ingested by toddlers. We describe 11 cases of clonidine ingestion by toddlers (mean dose 0.15 mg/kg; range 0.01 to 0.57). The source of the clonidine was a grandparent in six of 11 cases. Symptoms included altered level of consciousness (n = 11), mi...
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Veröffentlicht in: | Critical care medicine 1990-10, Vol.18 (10), p.1124-1128 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Clonidine may be a source of serious toxicity when ingested by toddlers. We describe 11 cases of clonidine ingestion by toddlers (mean dose 0.15 mg/kg; range 0.01 to 0.57). The source of the clonidine was a grandparent in six of 11 cases. Symptoms included altered level of consciousness (n = 11), miosis (n = 5), brady-cardia (n = 8), hypotension (n = 5), apnea and respiratory depression (n = 6), hypothermia (n = 5) and hypertension (n = 3). Therapeutic interventions included naloxone (n = 8) and atropine (n = 4), dopamine (n = 1), fluid resuscitation (n = 4), and endotracheal intubation (n = 1). There were no deaths. Symptoms of clonidine ingestion were typically mild if the dose ingested was 0.01 mg/kg. Apnea and respiratory depression were common when the dose exceeded 0.02 mg/kg. More effective measures are needed to prevent these potentially serious intoxications. |
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ISSN: | 0090-3493 1530-0293 |
DOI: | 10.1097/00003246-199010000-00014 |