The effect of culture conditions on the production of erythromycin by Saccharopolyspora erythraea in batch culture

Saccharopolyspora erythraea growth is inhibited when grown at a low constant dissolved oxygen tension (DOT) of 10% air saturation. However, the specific erythromycin production is virtually identical to that of a culture where the DOT did not fall below 65%. In addition, at constant DOT (10%) a stir...

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Veröffentlicht in:	Biotechnology letters 1996-10, Vol.18 (10), p.1181-1186
Hauptverfasser:	HEYDARIAN, S. M, LILLY, M. D, ISON, A. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biotechnology Fundamental and applied biological sciences. Psychology Methods. Procedures. Technologies Microbial engineering. Fermentation and microbial culture technology Saccharopolyspora erythraea
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Zusammenfassung:	Saccharopolyspora erythraea growth is inhibited when grown at a low constant dissolved oxygen tension (DOT) of 10% air saturation. However, the specific erythromycin production is virtually identical to that of a culture where the DOT did not fall below 65%. In addition, at constant DOT (10%) a stirrer speed of 750 rpm in a 7 litre causes mechanical damage to the mycelia in comparison with result at 500 rpm.
ISSN:	0141-5492 1573-6776
DOI:	10.1007/BF00128589