Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cells
Cell and tissue growth is regulated through a complex interplay of stimulatory and inhibitory signals. We describe two biological actions of transforming growth factor beta 1 (TGF-beta 1) in primary cultures of rabbit uterine epithelial cells: (i) inhibition of cell proliferation and (ii) a concomit...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1991-04, Vol.88 (8), p.3412-3415 |
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| container_end_page | 3415 |
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| container_issue | 8 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 88 |
| creator | Rotello, R J Lieberman, R C Purchio, A F Gerschenson, L E |
| description | Cell and tissue growth is regulated through a complex interplay of stimulatory and inhibitory signals. We describe two biological actions of transforming growth factor beta 1 (TGF-beta 1) in primary cultures of rabbit uterine epithelial cells: (i) inhibition of cell proliferation and (ii) a concomitant increase in cells undergoing apoptosis (programmed cell death). It is proposed that proliferation and apoptosis together comprise normal cell growth regulation. |
| doi_str_mv | 10.1073/pnas.88.8.3412 |
| format | Article |
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We describe two biological actions of transforming growth factor beta 1 (TGF-beta 1) in primary cultures of rabbit uterine epithelial cells: (i) inhibition of cell proliferation and (ii) a concomitant increase in cells undergoing apoptosis (programmed cell death). 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We describe two biological actions of transforming growth factor beta 1 (TGF-beta 1) in primary cultures of rabbit uterine epithelial cells: (i) inhibition of cell proliferation and (ii) a concomitant increase in cells undergoing apoptosis (programmed cell death). It is proposed that proliferation and apoptosis together comprise normal cell growth regulation.</description><subject>Animals</subject><subject>apoptosis</subject><subject>Cell Division - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Cells, Cultured</subject><subject>DNA Damage - drug effects</subject><subject>Epithelial Cells</subject><subject>epithelium</subject><subject>Female</subject><subject>In Vitro Techniques</subject><subject>Nucleosomes - ultrastructure</subject><subject>Rabbits</subject><subject>Recombinant Proteins</subject><subject>Transforming Growth Factor beta - pharmacology</subject><subject>uterus</subject><subject>Uterus - cytology</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkb2P1DAQxS0EOpa7a-mQXF2XYDtO7Eg0aMWXdBLNUVtOPN418trBdoDr-cNJ2OW0NFw1xXu_NzN6CL2kpKZENK-noHMtZS3rhlP2BG0o6WnV8Z48RRtCmKgkZ_w5epHzV0JI30pygS4YoZx1bIN-bWNMxgVdwOAEu9nr4mLA0WI9xanE7DLWweARvMdTit5ZSEfPcI9L0iHbmA4u7PAuxR9lj60eS0x4gKIxxS7gcfZlTkv-XCC5ABgmV_bgnfZ_YvMVema1z3B9mpfoy_t3d9uP1e3nD5-2b2-rkXdtqczAoSG2HVlHrTVGMN4K3ouedAakHIwVHBhp6Ng2TAx0FFoPlBghtBFG6OYSvTnmTvNwADNCWO73akruoNO9itqpf5Xg9moXv6uWLpsW_OaEp_hthlzUweX1AR0gzllJ0lLCKX3USNue0rYji7E-GscUc05gH26hRK31qrVeJaWSaq13AV6df_BgP_V5pq_cX_Wcv_mfruzsfYGfpfkNp_G9Ug</recordid><startdate>19910415</startdate><enddate>19910415</enddate><creator>Rotello, R J</creator><creator>Lieberman, R C</creator><creator>Purchio, A F</creator><creator>Gerschenson, L E</creator><general>National Acad Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19910415</creationdate><title>Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cells</title><author>Rotello, R J ; Lieberman, R C ; Purchio, A F ; Gerschenson, L E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-db4e30f5c261ffdd72457497906de88bdf74e2031c5327b1c7aab10d77ad7d7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Animals</topic><topic>apoptosis</topic><topic>Cell Division - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Cells, Cultured</topic><topic>DNA Damage - drug effects</topic><topic>Epithelial Cells</topic><topic>epithelium</topic><topic>Female</topic><topic>In Vitro Techniques</topic><topic>Nucleosomes - ultrastructure</topic><topic>Rabbits</topic><topic>Recombinant Proteins</topic><topic>Transforming Growth Factor beta - pharmacology</topic><topic>uterus</topic><topic>Uterus - cytology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rotello, R J</creatorcontrib><creatorcontrib>Lieberman, R C</creatorcontrib><creatorcontrib>Purchio, A F</creatorcontrib><creatorcontrib>Gerschenson, L E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rotello, R J</au><au>Lieberman, R C</au><au>Purchio, A F</au><au>Gerschenson, L E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cells</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1991-04-15</date><risdate>1991</risdate><volume>88</volume><issue>8</issue><spage>3412</spage><epage>3415</epage><pages>3412-3415</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Cell and tissue growth is regulated through a complex interplay of stimulatory and inhibitory signals. 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| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1991-04, Vol.88 (8), p.3412-3415 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_15911560 |
| source | MEDLINE; Jstor Complete Legacy; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals apoptosis Cell Division - drug effects Cell Survival - drug effects Cells, Cultured DNA Damage - drug effects Epithelial Cells epithelium Female In Vitro Techniques Nucleosomes - ultrastructure Rabbits Recombinant Proteins Transforming Growth Factor beta - pharmacology uterus Uterus - cytology |
| title | Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cells |
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