Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cells

Cell and tissue growth is regulated through a complex interplay of stimulatory and inhibitory signals. We describe two biological actions of transforming growth factor beta 1 (TGF-beta 1) in primary cultures of rabbit uterine epithelial cells: (i) inhibition of cell proliferation and (ii) a concomit...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1991-04, Vol.88 (8), p.3412-3415
Hauptverfasser:	Rotello, R J, Lieberman, R C, Purchio, A F, Gerschenson, L E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apoptosis Cell Division - drug effects Cell Survival - drug effects Cells, Cultured DNA Damage - drug effects Epithelial Cells epithelium Female In Vitro Techniques Nucleosomes - ultrastructure Rabbits Recombinant Proteins Transforming Growth Factor beta - pharmacology uterus Uterus - cytology
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Beschreibung
Zusammenfassung:	Cell and tissue growth is regulated through a complex interplay of stimulatory and inhibitory signals. We describe two biological actions of transforming growth factor beta 1 (TGF-beta 1) in primary cultures of rabbit uterine epithelial cells: (i) inhibition of cell proliferation and (ii) a concomitant increase in cells undergoing apoptosis (programmed cell death). It is proposed that proliferation and apoptosis together comprise normal cell growth regulation.
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.88.8.3412