Development regulation of glucosidase I, an enzyme involved in the processing of asparagine-linked glycoproteins in rat mammary gland
Glucosidase I involved in the processing of N-linked glycoproteins was purified to homogeneity from the lactating rat mammary gland. The findings suggest that the accumulation of glucosidase I is modulated as a function of gland ontogeny. The immunoprecipitation of soluble extracts from ( super(35)S...
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Veröffentlicht in: | The Journal of biological chemistry 1990-01, Vol.265 (17), p.9701-9706 |
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container_title | The Journal of biological chemistry |
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creator | Shailubhai, K Saxena, E S Balapure, A K Vijay, I K |
description | Glucosidase I involved in the processing of N-linked glycoproteins was purified to homogeneity from the lactating rat mammary gland. The findings suggest that the accumulation of glucosidase I is modulated as a function of gland ontogeny. The immunoprecipitation of soluble extracts from ( super(35)S)methionine-labeled tissue with anti-rat alpha -lactalbumin antibodies indicates that these hormones not only stimulate the synthesis of alpha -lactalbumin but also play an important role in its glycosylation. |
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The findings suggest that the accumulation of glucosidase I is modulated as a function of gland ontogeny. The immunoprecipitation of soluble extracts from ( super(35)S)methionine-labeled tissue with anti-rat alpha -lactalbumin antibodies indicates that these hormones not only stimulate the synthesis of alpha -lactalbumin but also play an important role in its glycosylation.</description><identifier>ISSN: 0021-9258</identifier><language>eng</language><subject>asparagine ; glucosidase I</subject><ispartof>The Journal of biological chemistry, 1990-01, Vol.265 (17), p.9701-9706</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Shailubhai, K</creatorcontrib><creatorcontrib>Saxena, E S</creatorcontrib><creatorcontrib>Balapure, A K</creatorcontrib><creatorcontrib>Vijay, I K</creatorcontrib><title>Development regulation of glucosidase I, an enzyme involved in the processing of asparagine-linked glycoproteins in rat mammary gland</title><title>The Journal of biological chemistry</title><description>Glucosidase I involved in the processing of N-linked glycoproteins was purified to homogeneity from the lactating rat mammary gland. The findings suggest that the accumulation of glucosidase I is modulated as a function of gland ontogeny. The immunoprecipitation of soluble extracts from ( super(35)S)methionine-labeled tissue with anti-rat alpha -lactalbumin antibodies indicates that these hormones not only stimulate the synthesis of alpha -lactalbumin but also play an important role in its glycosylation.</description><subject>asparagine</subject><subject>glucosidase I</subject><issn>0021-9258</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><recordid>eNqNi81OwzAQhH0AiZbyDnvqiUj5IUpzLqD23nu1SjbGYK9TrxMp3HlvXKkP0LnMSPN9D2qV52WRtWW9e1Jrke885a0tVurvnWayfnTEEQLpyWI0nsEPoO3UeTE9CsHxFZCB-HdxBIZnb2fq04D4RTAG35GIYX3VUEYMqA1TZg3_JEzbpfMJimRYrlLACA6dw7CkE7nfqMcBrdDLrZ_V9vPjtD9kybpMJPHsjHRkE0t-knNRt0XeVE11N_gP91RWGg</recordid><startdate>19900101</startdate><enddate>19900101</enddate><creator>Shailubhai, K</creator><creator>Saxena, E S</creator><creator>Balapure, A K</creator><creator>Vijay, I K</creator><scope>7QL</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M81</scope><scope>P64</scope></search><sort><creationdate>19900101</creationdate><title>Development regulation of glucosidase I, an enzyme involved in the processing of asparagine-linked glycoproteins in rat mammary gland</title><author>Shailubhai, K ; Saxena, E S ; Balapure, A K ; Vijay, I K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_159107373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>asparagine</topic><topic>glucosidase I</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shailubhai, K</creatorcontrib><creatorcontrib>Saxena, E S</creatorcontrib><creatorcontrib>Balapure, A K</creatorcontrib><creatorcontrib>Vijay, I K</creatorcontrib><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 3</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>The Journal of biological chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shailubhai, K</au><au>Saxena, E S</au><au>Balapure, A K</au><au>Vijay, I K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development regulation of glucosidase I, an enzyme involved in the processing of asparagine-linked glycoproteins in rat mammary gland</atitle><jtitle>The Journal of biological chemistry</jtitle><date>1990-01-01</date><risdate>1990</risdate><volume>265</volume><issue>17</issue><spage>9701</spage><epage>9706</epage><pages>9701-9706</pages><issn>0021-9258</issn><abstract>Glucosidase I involved in the processing of N-linked glycoproteins was purified to homogeneity from the lactating rat mammary gland. The findings suggest that the accumulation of glucosidase I is modulated as a function of gland ontogeny. The immunoprecipitation of soluble extracts from ( super(35)S)methionine-labeled tissue with anti-rat alpha -lactalbumin antibodies indicates that these hormones not only stimulate the synthesis of alpha -lactalbumin but also play an important role in its glycosylation.</abstract></addata></record> |
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language | eng |
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source | Alma/SFX Local Collection; EZB Electronic Journals Library |
subjects | asparagine glucosidase I |
title | Development regulation of glucosidase I, an enzyme involved in the processing of asparagine-linked glycoproteins in rat mammary gland |
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