Effect of nifedipine and anticonvulsants of kainic acid-induced seizures in mice
The calcium-channel inhibitor nifedipine and several anticonvulsant drugs were evaluated for effects on seizures induced by intracerebroventricular injection of 0.14 μg of kainic acid. These seizures were markedly exacerbated by valproic acid and moderately inhibited by diazepam. Nifedipine decrease...
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| Veröffentlicht in: | Brain research 1990-11, Vol.533 (1), p.157-160 |
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| container_title | Brain research |
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| creator | Braun, Dale E. Freed, William J. |
| description | The calcium-channel inhibitor nifedipine and several anticonvulsant drugs were evaluated for effects on seizures induced by intracerebroventricular injection of 0.14 μg of kainic acid. These seizures were markedly exacerbated by valproic acid and moderately inhibited by diazepam. Nifedipine decreased the duration of each individual seizure episode, but did not block the development of seizures. It is concluded that nifedipine prevents the maintenance or propagation of kainate-induced seizures. |
| doi_str_mv | 10.1016/0006-8993(90)91810-4 |
| format | Article |
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These seizures were markedly exacerbated by valproic acid and moderately inhibited by diazepam. Nifedipine decreased the duration of each individual seizure episode, but did not block the development of seizures. It is concluded that nifedipine prevents the maintenance or propagation of kainate-induced seizures.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(90)91810-4</identifier><identifier>PMID: 2085727</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Anticonvulsant ; Anticonvulsants - therapeutic use ; Biological and medical sciences ; Calcium channel inhibitor ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Excitatory amino acid ; Female ; Fundamental and applied biological sciences. 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Psychology</subject><subject>Kainic acid</subject><subject>Kainic Acid - antagonists & inhibitors</subject><subject>Mice</subject><subject>Nifedipine</subject><subject>Nifedipine - therapeutic use</subject><subject>Reaction Time - drug effects</subject><subject>Seizure</subject><subject>Seizures - chemically induced</subject><subject>Seizures - drug therapy</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2LFDEQhoMo67j6DxT6ouihtfLR6c5FkGX9gAU96DlkKhUo7UmPyfSC_nozzrDePBSpUE-9FI8QTyW8liDtGwCw_eScfunglZOThN7cExs5jaq3ysB9sblDHopHtX5vX60dXIgLBdMwqnEjvlynRHjoltRlThR5z5m6kGOrA-OSb9e5trYeiR-BM2MXkGPPOa5IsavEv9dCtePc7RjpsXiQwlzpyfm9FN_eX3-9-tjffP7w6erdTY9GTofeDtGNW2sUSesAETRhDFHpLY5W2dEma8DYKC0NOoG228kGp6weRwQVJn0pXpxy92X5uVI9-B1XpHkOmZa1ejk4CYMdGmhOIJal1kLJ7wvvQvnlJfijSH-05I-WvAP_V6Q3be3ZOX_d7ijeLZ3Ntfnz8zxUDHMqISPXf9nODEMLb9zbE0dNxi1T8RWZclPHpYn3ceH_H_IHzhiN_Q</recordid><startdate>19901112</startdate><enddate>19901112</enddate><creator>Braun, Dale E.</creator><creator>Freed, William J.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19901112</creationdate><title>Effect of nifedipine and anticonvulsants of kainic acid-induced seizures in mice</title><author>Braun, Dale E. ; Freed, William J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-65d97b642e1690cc03ecdad23bc762676f64046d16e53f036b86a926377c02a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Anticonvulsant</topic><topic>Anticonvulsants - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Calcium channel inhibitor</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Excitatory amino acid</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Kainic acid</topic><topic>Kainic Acid - antagonists & inhibitors</topic><topic>Mice</topic><topic>Nifedipine</topic><topic>Nifedipine - therapeutic use</topic><topic>Reaction Time - drug effects</topic><topic>Seizure</topic><topic>Seizures - chemically induced</topic><topic>Seizures - drug therapy</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Braun, Dale E.</creatorcontrib><creatorcontrib>Freed, William J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Braun, Dale E.</au><au>Freed, William J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of nifedipine and anticonvulsants of kainic acid-induced seizures in mice</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1990-11-12</date><risdate>1990</risdate><volume>533</volume><issue>1</issue><spage>157</spage><epage>160</epage><pages>157-160</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The calcium-channel inhibitor nifedipine and several anticonvulsant drugs were evaluated for effects on seizures induced by intracerebroventricular injection of 0.14 μg of kainic acid. These seizures were markedly exacerbated by valproic acid and moderately inhibited by diazepam. Nifedipine decreased the duration of each individual seizure episode, but did not block the development of seizures. It is concluded that nifedipine prevents the maintenance or propagation of kainate-induced seizures.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>2085727</pmid><doi>10.1016/0006-8993(90)91810-4</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Brain research, 1990-11, Vol.533 (1), p.157-160 |
| issn | 0006-8993 1872-6240 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Anticonvulsant Anticonvulsants - therapeutic use Biological and medical sciences Calcium channel inhibitor Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Excitatory amino acid Female Fundamental and applied biological sciences. Psychology Kainic acid Kainic Acid - antagonists & inhibitors Mice Nifedipine Nifedipine - therapeutic use Reaction Time - drug effects Seizure Seizures - chemically induced Seizures - drug therapy Vertebrates: nervous system and sense organs |
| title | Effect of nifedipine and anticonvulsants of kainic acid-induced seizures in mice |
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