Effect of nifedipine and anticonvulsants of kainic acid-induced seizures in mice

The calcium-channel inhibitor nifedipine and several anticonvulsant drugs were evaluated for effects on seizures induced by intracerebroventricular injection of 0.14 μg of kainic acid. These seizures were markedly exacerbated by valproic acid and moderately inhibited by diazepam. Nifedipine decrease...

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Veröffentlicht in:	Brain research 1990-11, Vol.533 (1), p.157-160
Hauptverfasser:	Braun, Dale E., Freed, William J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsant Anticonvulsants - therapeutic use Biological and medical sciences Calcium channel inhibitor Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Excitatory amino acid Female Fundamental and applied biological sciences. Psychology Kainic acid Kainic Acid - antagonists & inhibitors Mice Nifedipine Nifedipine - therapeutic use Reaction Time - drug effects Seizure Seizures - chemically induced Seizures - drug therapy Vertebrates: nervous system and sense organs
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Zusammenfassung:	The calcium-channel inhibitor nifedipine and several anticonvulsant drugs were evaluated for effects on seizures induced by intracerebroventricular injection of 0.14 μg of kainic acid. These seizures were markedly exacerbated by valproic acid and moderately inhibited by diazepam. Nifedipine decreased the duration of each individual seizure episode, but did not block the development of seizures. It is concluded that nifedipine prevents the maintenance or propagation of kainate-induced seizures.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(90)91810-4