Toxic cardiogenic shock associated with infusion of 5-fluorouracil

Cardiac toxicity related to the use of 5-fluorouracil (5-FU) is a rare occurrence. The few case reports describe anginal pain with transient ECG changes. Myocardial failure has not been reported. We describe an episode of acute reversible toxic cardiogenic shock related to continuous infusion of 5-F...

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Veröffentlicht in:	The American heart journal 1989-07, Vol.118 (1), p.184-186
Hauptverfasser:	McKendall, George R., Shurman, Alan, Anamur, Murat, Most, Albert S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Drug toxicity and drugs side effects treatment Electrocardiography Fluorouracil - adverse effects Hemodynamics - drug effects Humans Infusions, Intravenous Male Medical sciences Middle Aged Pharmacology. Drug treatments Shock, Cardiogenic - chemically induced Shock, Cardiogenic - physiopathology Shock, Cardiogenic - therapy Toxicity: cardiovascular system
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Beschreibung
Zusammenfassung:	Cardiac toxicity related to the use of 5-fluorouracil (5-FU) is a rare occurrence. The few case reports describe anginal pain with transient ECG changes. Myocardial failure has not been reported. We describe an episode of acute reversible toxic cardiogenic shock related to continuous infusion of 5-FU.
ISSN:	0002-8703 1097-6744
DOI:	10.1016/0002-8703(89)90095-1