The embryonic development of mammalian neural tube defects

The embryonic development of mammalian neural tube defects

Neural tube defects (NTD) are among the most prevalent of congenital malformations. In this article the authors review the current state of knowledge concerning the developmental mechanisms that underlie NTD in mammalian, principally rodent, model systems and ask to what extent these models contribu...

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Veröffentlicht in:Progress in neurobiology 1990, Vol.35 (5), p.363-403
Hauptverfasser: COPP, A. J, BROOK, F. A, ESTIBEIRO, J. P, SHUM, A. S. W, COCKROFT, D. L
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Central Nervous System - embryology
Disease Models, Animal
Environment
Genes
Humans
Mammalia
Mammals - embryology
Medical sciences
Nervous system involvement in other diseases. Miscellaneous
Neural Tube Defects - chemically induced
Neural Tube Defects - embryology
Neural Tube Defects - genetics
Neurology
Teratogens
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Zusammenfassung:Neural tube defects (NTD) are among the most prevalent of congenital malformations. In this article the authors review the current state of knowledge concerning the developmental mechanisms that underlie NTD in mammalian, principally rodent, model systems and ask to what extent these models contribute information of value to an understanding of the pathogenesis of human NTD.
ISSN:0301-0082
1873-5118
DOI:10.1016/0301-0082(90)90037-H