Physical analysis of the region deleted in the t super(w18) allele of the mouse tcl-4 complementation group

Physical analysis of the region deleted in the t super(w18) allele of the mouse tcl-4 complementation group

We have generated a YAC contig of at least 3.3 Mb from the proximal region of In(17)4 of mouse chromosome 17. This region corresponds to DNA lost in the gastrulation mutant t super(w18), which belongs to the tcl-4 complementation group. Our most proximal and distal probes lie within the deletion-3.3...

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Veröffentlicht in:Genomics (San Diego, Calif.) Calif.), 1996-08, Vol.36 (1), p.39-46
Hauptverfasser: Barclay, J, King, T F, Crossley, PH, Barnard, R C, Larin, Z, Lehrach, H, Little, PFR
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Sprache:eng
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Zusammenfassung:We have generated a YAC contig of at least 3.3 Mb from the proximal region of In(17)4 of mouse chromosome 17. This region corresponds to DNA lost in the gastrulation mutant t super(w18), which belongs to the tcl-4 complementation group. Our most proximal and distal probes lie within the deletion-3.3 Mb apart-indicating that we have not cloned the entire region. The deleted region is contained in a genetic interval of less than 1 cM, suggesting that some suppression of recombination must occur.
ISSN:0888-7543