Inflammation of guinea pig dermis. Effects of leukotriene B sub(4) receptor antagonist, SC-41930

Neutrophil (PMNL) infiltration is a prominent feature of human psoriasis. Psoriatic skin lesions contain abnormally high amounts of leukotriene B sub(4) (LTB sub(4)), itself a potent PMNL chemoattractant both in vivo and in vitro. SC-41930 (7-(3-(4-acetyl-3-methoxy-2-propylphenoxy)-propoxy)-3,4-dihydro-8- propyl-2H-1-benzopyran-2-carboxylic acid), an orally active LTB sub(4) receptor antagonist, was tested topically in models of skin inflammation. The models possess many of the characteristics of human psoriasis, and agents such as SC-41930 that demonstrate activity in these models may well have therapeutic utility in the treatment of human psoriasis.