The B cell antigen CD75 is a cell surface sialyltransferase

In this work we have isolated a cDNA clone encoding the B cell antigen CD75. The amino acid sequence of CD75 is shown to be identical to that of human alpha 2,6 sialyltransferase, believed to be primarily associated with the Golgi complex. This is the first demonstration of cell surface expression o...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of experimental medicine 1990-08, Vol.172 (2), p.641-643
Hauptverfasser:	STAMENKOVIC, I, ASHEIM, H. C, DEGGERDAL, A, BLOMHOFF, H. K, SMELAND, E. B, FUNDERUD, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences CD75 antigen Fundamental and applied biological sciences. Psychology Fundamental immunology Immunobiology lymphocytes B Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation sialyltransferase
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	In this work we have isolated a cDNA clone encoding the B cell antigen CD75. The amino acid sequence of CD75 is shown to be identical to that of human alpha 2,6 sialyltransferase, believed to be primarily associated with the Golgi complex. This is the first demonstration of cell surface expression of sialyltransferase which, in B cells, may play an important role in intercellular adhesion and antigen presentation events.
ISSN:	0022-1007 1540-9538
DOI:	10.1084/jem.172.2.641