Cytotoxicity of human eosinophil granule major basic protein to human nasal sinus mucosa in vitro

The toxic effects of the human eosinophil granule major basic protein (MBP), reduced and alkylated, were studied on human nasal mucosa in vitro. With a microscope coupled with a television monitor (magnification ×2500) and videotape recorder, we investigated the effects of MBP on the mucosa and the...

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Veröffentlicht in:	Journal of allergy and clinical immunology 1990-07, Vol.86 (1), p.52-63
Hauptverfasser:	Hisamatsu, Ken-ichi, Ganbo, Tetsuya, Nakazawa, Tsutomu, Murakami, Yoshihiko, Gleich, Gerald J., Makiyama, Kiyoshi, Koyama, Hideaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood Proteins - isolation & purification Blood Proteins - toxicity Cilia - drug effects Cilia - pathology Culture Techniques Dose-Response Relationship, Drug Eosinophil Granule Proteins Eosinophils - metabolism Ethmoid Sinus - drug effects Ethmoid Sinus - pathology Humans Immunopathology Maxillary Sinus - drug effects Maxillary Sinus - pathology Medical sciences Nasal Mucosa - drug effects Nasal Mucosa - pathology Respiratory Hypersensitivity - pathology Ribonucleases
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Zusammenfassung:	The toxic effects of the human eosinophil granule major basic protein (MBP), reduced and alkylated, were studied on human nasal mucosa in vitro. With a microscope coupled with a television monitor (magnification ×2500) and videotape recorder, we investigated the effects of MBP on the mucosa and the ciliary activity of single cells. In nasal mucosal specimens from normal individuals, MBP, 5 μmol/L and 10 μmol/L, significantly inhibited ( p
ISSN:	0091-6749 1097-6825
DOI:	10.1016/S0091-6749(05)80123-X