5-Fluorouracil Derivatives XX. : Synthesis and Antitumor Activity of 5'-O-Unsaturated Acyl-5-fluorouridines

Various kinds of 5'-O-unsaturated acyl 5-fluorouridines were synthesized to obtain 5-fluorouridine derivatives with low toxicity and high antitumor activity. Antitumor activity of the compounds against L-1210 leukemia in mice was examined, and the 5'-O-4-opentenoyl derivative showed the hi...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1990/11/25, Vol.38(11), pp.3164-3166
Hauptverfasser: OZAKI, Shoichiro, AKIYAMA, Takahiko, MORITA, Takao, KUMEGAWA, Masahiro, NAGASE, Toshio, UEHARA, Nobuaki, HOSHI, Akio
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Sprache:eng
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Zusammenfassung:Various kinds of 5'-O-unsaturated acyl 5-fluorouridines were synthesized to obtain 5-fluorouridine derivatives with low toxicity and high antitumor activity. Antitumor activity of the compounds against L-1210 leukemia in mice was examined, and the 5'-O-4-opentenoyl derivative showed the highest antitumor activity.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.38.3164