5-Fluorouracil Derivatives XX. : Synthesis and Antitumor Activity of 5'-O-Unsaturated Acyl-5-fluorouridines
Various kinds of 5'-O-unsaturated acyl 5-fluorouridines were synthesized to obtain 5-fluorouridine derivatives with low toxicity and high antitumor activity. Antitumor activity of the compounds against L-1210 leukemia in mice was examined, and the 5'-O-4-opentenoyl derivative showed the hi...
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Veröffentlicht in: | Chemical & pharmaceutical bulletin 1990/11/25, Vol.38(11), pp.3164-3166 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Various kinds of 5'-O-unsaturated acyl 5-fluorouridines were synthesized to obtain 5-fluorouridine derivatives with low toxicity and high antitumor activity. Antitumor activity of the compounds against L-1210 leukemia in mice was examined, and the 5'-O-4-opentenoyl derivative showed the highest antitumor activity. |
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ISSN: | 0009-2363 1347-5223 |
DOI: | 10.1248/cpb.38.3164 |