Determination of Micronutrients and Oxidative Stress Status in the Blood of STZ-Induced Experimental Diabetic Rat Models

This study aims to research the effect of streptozotocin (STZ) at different doses on the serum micronutrients and oxidative stress status in diabetic rat models. Twenty male rats averaged 250 g and 3–4 months old were used as experimental models. They were put in four groups composed of five rats ea...

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Veröffentlicht in:	Cell biochemistry and biophysics 2014-11, Vol.70 (2), p.933-938
Hauptverfasser:	Ragbetli, Cennet, Dede, Semiha, Tanritanir, Pinar, Yoruk, İbrahim Hakki, Ragbetli, Murat Cetin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Biotechnology Cell Biology Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - metabolism Disease Models, Animal Dose-Response Relationship, Drug Life Sciences Male Micronutrients Micronutrients - blood Original Paper Oxidative stress Oxidative Stress - drug effects Pharmacology/Toxicology Rats Rats, Wistar Streptozocin - pharmacology Vitamins Zinc
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Beschreibung
Zusammenfassung:	This study aims to research the effect of streptozotocin (STZ) at different doses on the serum micronutrients and oxidative stress status in diabetic rat models. Twenty male rats averaged 250 g and 3–4 months old were used as experimental models. They were put in four groups composed of five rats each. Diabetic was induced by administering STZ 55 and 65 mg/kg intraperitonally. The serum micronutrients including minerals and vitamins (Cu, Zn, Mg, Fe, vitamins D, E, and C) and oxidative stress (malondialdehyde, MDA) were determined. Cu, Zn, and Vitamin D3 levels were found to increase significantly in STZ groups ( p
ISSN:	1085-9195 1559-0283
DOI:	10.1007/s12013-014-0001-x