Effect of NO Synthase Blockade on NO Production in Rat Heart under Conditions of Hypokinesia

Electron paramagnetic (EPR) spectroscopy study showed that 90-day hypokinesia in rats is accompanied by an increase in NO production in the heart. A nonselective NO synthase inhibitor L-NAME decreased the content of NO in the heart atria and ventricles of hypokinetic rats by 67-70%. A selective inhi...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2014-09, Vol.157 (5), p.545-547
Hauptverfasser:	Zaripova, R. I., Gainutdinov, Kh. L., Zefirov, T. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Cell Biology Electron Spin Resonance Spectroscopy Immobilization Internal Medicine Laboratory Medicine Myocardium - enzymology Myocardium - metabolism Nitric Oxide - biosynthesis Nitric Oxide Synthase - antagonists & inhibitors Pathology Rats
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Zusammenfassung:	Electron paramagnetic (EPR) spectroscopy study showed that 90-day hypokinesia in rats is accompanied by an increase in NO production in the heart. A nonselective NO synthase inhibitor L-NAME decreased the content of NO in the heart atria and ventricles of hypokinetic rats by 67-70%. A selective inhibitor of inducible NO synthase, aminoguanidine, also decreased the level of NO in the heart atria and ventricles of hypokinetic rats by 60-65%. Our results indicate that the increase in NO production during hypokinesia is associated with activation of NO synthases.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-014-2610-1