The diagnostic value of SE MRI and DWI of the spine in patients with monoclonal gammopathy of undetermined significance, smouldering myeloma and multiple myeloma

Objectives To evaluate DWI of the bone marrow in the differentiation of monoclonal gammopathy of undetermined significance (MGUS), smouldering myeloma (SMM) and multiple myeloma (MM). Methods The retrospective study includes 64 patients with MGUS, 27 with SMM, 64 with new MM and 12 controls. Signal...

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Veröffentlicht in:	European radiology 2014-11, Vol.24 (11), p.2754-2765
Hauptverfasser:	Dutoit, Julie C., Vanderkerken, Matthias A., Anthonissen, Joris, Dochy, Frederick, Verstraete, Koenraad L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biopsy Bone marrow Bone Marrow - pathology Diagnosis, Differential Diagnostic Radiology Diffusion Magnetic Resonance Imaging - methods Female Follow-Up Studies Humans Imaging Internal Medicine Interventional Radiology Lumbar Vertebrae - pathology Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medicine Medicine & Public Health Middle Aged Monoclonal Gammopathy of Undetermined Significance - diagnosis Multiple myeloma Multiple Myeloma - diagnosis Musculoskeletal Neuroradiology Patients Plasma Plasma Cells - pathology Radiology Reproducibility of Results Retrospective Studies Thoracic Vertebrae - pathology Ultrasound Working groups
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Zusammenfassung:	Objectives To evaluate DWI of the bone marrow in the differentiation of monoclonal gammopathy of undetermined significance (MGUS), smouldering myeloma (SMM) and multiple myeloma (MM). Methods The retrospective study includes 64 patients with MGUS, 27 with SMM, 64 with new MM and 12 controls. Signal intensity (SI) of spinal SE-MRI and DWI (b0-1000) as well as apparent diffusion coefficients (ADC) were measured in the T10 and L3. Qualitative assessment of b-images was performed by one experienced radiologist. Results ADC600 and ADC1000 are the best ADC values in differentiating patient groups ( p
ISSN:	0938-7994 1432-1084
DOI:	10.1007/s00330-014-3324-5