Selective Uncaging of DNA through Reaction Rate Selectivity

Selective Uncaging of DNA through Reaction Rate Selectivity

The synthesis and use of the new nucleobase-caged nucleotides dT pHP and dT NDEACM is reported. Through a combination of time and wavelength selectivity four levels of selective uncaging with only two cages, and only two wavelengths, were obtained. The new residue dT pHP can be uncaged at 313 nm wit...

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Veröffentlicht in:Organic letters 2014-10, Vol.16 (19), p.5128-5131
Hauptverfasser: Rodrigues-Correia, Alexandre, Knapp-Bühle, Diana, Engels, Joachim W, Heckel, Alexander
Format: Artikel
Sprache:eng
Schlagworte:
DNA - chemistry
Molecular Structure
Nucleotides - chemical synthesis
Nucleotides - chemistry
Solid-Phase Synthesis Techniques
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Zusammenfassung:The synthesis and use of the new nucleobase-caged nucleotides dT pHP and dT NDEACM is reported. Through a combination of time and wavelength selectivity four levels of selective uncaging with only two cages, and only two wavelengths, were obtained. The new residue dT pHP can be uncaged at 313 nm without the formation of unwanted cyclic pyridine dimers.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol502478g